English: Linda Buck’s research has transformed the field of odorant perception through the cloning of mammalian olfactory receptors. Together with Richard Axel, Buck developed an ingenious method to identify a G protein-coupled odorant receptor family of unprecedented size, comprising up to 1000 distinct genes members. Buck then used olfactory receptor genes as molecular tools to gain insight into the mechanisms and organisations strategies underlying odor perception. Her work showed that the olfactory epithelium is comprised of spatial zones that express different sets of receptor genes and that each zone is a mosaic of randomly interspersed neurons expressing different receptors. Buck then showed that individual olfactory neurons express a single receptor gene. In later work, Buck has documented the organization of olfactory axonal projections into the brain. Buck’s work has been recognised by award of the 2004 Nobel Prize.

This work is free and may be used by anyone for any purpose. If you wish to use this content, you do not need to request permission as long as you follow any licensing requirements mentioned on this page. The Wikimedia Foundation has received an e-mail confirming that the copyright holder has approved publication under the terms mentioned on this page. This correspondence has been reviewed by a Volunteer Response Team (VRT) member and stored in our permission archive. The correspondence is available to trusted volunteers as ticket #2014062710019796. If you have questions about the archived correspondence, please use the VRT noticeboard. Ticket link: https://ticket.wikimedia.org/otrs/index.pl?Action=AgentTicketZoom&TicketNumber=2014062710019796 Find other files from the same ticket: